Autosomal dominant mannose-binding lectin deficiency is associated with worse neurodevelopmental outcomes after cardiac surgery in infants
نویسندگان
چکیده
منابع مشابه
Neurodevelopmental outcomes after cardiac surgery in infancy.
BACKGROUND Neurodevelopmental disability is the most common complication for survivors of surgery for congenital heart disease (CHD). METHODS We analyzed individual participant data from studies of children evaluated with the Bayley Scales of Infant Development, second edition, after cardiac surgery between 1996 and 2009. The primary outcome was Psychomotor Development Index (PDI), and the se...
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One of the important parts of innate immunity is complement system that occurs in three different ways; the classic, the alternative and the lectin pathway. The four pattern recognition molecules that have been identified till now are Mannose binding lectin (MBL), a component of lectin pathway, and three ficolins (ficolin1,-2 and -3) which compound to the carbohydrates of the cell surface. MBL ...
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OBJECTIVES Mannose-binding lectin (MBL) and ficolins activate the complement cascade, which is involved in atherogenesis. Based on a pilot study, we hypothesized that functional polymorphisms in the MBL gene (MBL2) leading to dysfunctional protein are related to development of myocardial infarction (MI). The aim of the present study was to study polymorphisms in MBL2 and ficolin genes in relati...
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To the Editor—We read with great interest the article by Eisen et al. [1], in which the authors report an ambitious multivariable analysis of several articles on the impact of mannose-binding lectin (MBL) deficiency on the outcome of severe bacterial infection and sepsis. Although genetic polymorphisms in the genes encoding different molecules of the innate immune system have been associated wi...
متن کاملmannose-binding lectin deficiency in patients with a history of recurrent infections
mannose-binding lectin (mbl) is a protein of innate immune system that is involved in opsonization and complement activation. mbl deficiency is associated with predisposition to infectious diseases; however subnormal levels are also seen in healthy subjects. the aim of this study was to investigate the prevalence and clinical manifestation of mbl deficiency in patients with increased susceptibi...
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ژورنال
عنوان ژورنال: The Journal of Thoracic and Cardiovascular Surgery
سال: 2018
ISSN: 0022-5223
DOI: 10.1016/j.jtcvs.2017.08.035